แขนงวิชาภูมิคุ้มกันวิทยาคลินิก

ศาสตราจารย์ ดร.ชัชชัย  ตะยาภิวัฒนา

แขนงวิชาภูมิคุ้มกันวิทยาคลินิก
  :  chatchai.t@cmu.ac.th
  :  053-935080

ประวัติการศึกษา

  • วท.ด. (เทคโนโลยีชีวภาพ)
  • วท.ม. (จุลชีววิทยา)
  • วท.บ. (เทคนิคการแพทย์)

Research Expertise

  • Protein engineering for biologics development
  • Tailoring effector functions in therapeutic antibodies
  • Gene editing for cell therapy
  • Lateral-flow assays
  • Multiplex biosensors

  • 1. Khaodee W, Xiyuan G, Han MTT, Tayapiwatana C, Chiampanichayakul S, Anuchapreeda S, Cressey R. Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity. BMC Genomics 2024;25(1):82. doi: 10.1186/s12864-023-09888-z.
  • 2. Juntit OA, Sornsuwan K, Wisitponchai T, Sanghiran Lee V, Sakkhachornphop S, Yasamut U, Tayapiwatana C. Dimeric Ankyrin with inverted module promotes bifunctional property in capturing capsid to impede HIV-1 replication. Int. J. Mol. Sci 2023;24(6):5266. doi 10.3390/ijms24065266.
  • 3. Yimcharoen M, Saikaew S, Wattananandkul U, Phunpae P, Intorasoot S, Tayapiwatana C, Butr-Indr B. Mycobacterium tuberculosis adaptation in response to isoniazid treatment in a multi-stress system that mimics the host environment. Antibiotics 2023;12(5):852. doi 10.3390/antibiotics12050852.
  • 4. Thongkum W, Klayprasert P, Semakul N, Jakmunee J, Kasinrerk W, Setshedi M, Sayed Y, Tayapiwatana C. Semi-quantification and potency verification of the HIV protease inhibitor based on the matrix-capsid protein immobilized nickel (II)/NTA-Tol/graphene oxide/SPCE electrochemical biosensor. ACS Omega 2023;8(20):17932–40.
  • 5. Yasamut U, Thongkum W, Wongsawat E, Tayapiwatana C. Development of an immunochromatographic strip test for rapid detection of a potent neutralizing anti-interferon gamma antibody in adult-onset immunodeficiency. Asian Pac J Allergy Immunol 2023;2023(-):doi: 10.12932/AP-010523-1597.
  • 6. Chupradit K, Thongsin N, Tayapiwatana C, Wattanapanitch M. A precise gene delivery approach for human induced pluripotent stem cells using Cas9 RNP complex and recombinant AAV6 donor vectors. ProS One 2022;17(7):e0270963. doi 10.1371/journal. pone.0270963.
  • 7. Intasai N, Rangnoi K, Yamabhai M, Pamonsupornwichit T, Thongkum W, Yasamut U, Chupradit K, Takheaw N, Nimmanpipug P, Tayapiwatana C. Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147. Sci Rep 2022;12(1):6719. doi 10.1038/s41598-022-10657-3.
  • 8. Juntit OA, Yasamut U, Sakkhachornphop S, Chupradit K, Thongkum W, Srisawat C, Chokepaichitkool T, Kongtawelert P, Tayapiwatana C. Biological properties of reverse ankyrin engineered for dimer construction to enhance HIV-1 capsid interaction. Asian Pac J Allergy Immunol 2022;2022(-):22. doi 10.12932/AP-210122-1310.
  • 9. Juntit OA, Soponpong S, Thongkum W, Putpim C, Kasinrerk W, Tayapiwatana C. Production of a common epitope specific anti-ankyrin monoclonal antibody. J Assoc Med Sci 2022;55(2):23-30.
  • 10. Moonmuang S, Maniratanachote R, Chetprayoon P, Sornsuwan K, Thongkum W, Chupradit K, Tayapiwatana C. Specific interaction of DARPin with HIV-1 CA disturbs the distribution of gag, RNA packaging, and tetraspanin remodelling in the membrane. Viruses 2022;14(4):824. doi 10.3390/v14040824.
  • 11. Thongkum W, Thongheang K, Tayapiwatana C. The occluded epitope residing in spike receptor-binding motif is essential for cross-neutralization of SARS-CoV-2 delta variant. Curr Issues Mol Biol 2022;44(7):2842-55.
  • 12. Chupradit K, Khamaikawin W, Sakkhachornphop S, Puaninta C, Torbett BE, Borwornpinyo S, Hongeng S, Wattanapanitch M, Tayapiwatana C. Engineered zinc finger protein targeting 2LTR inhibits HIV integration in hematopoietic stem and progenitor cell-derived macrophages: In Vitro Study. Int J Mol Sci 2022;23(4):2331. doi 10.3390/ijms23042331.
  • 13. Hadpech S, Moonmuang S, Chupradit K, Yasamut U, Tayapiwatana C. Updating on roles of HIV intrinsic factors: A review of their antiviral mechanisms and emerging functions. Intervirology 2022;65(2):67-79.
  • 14. Kitro A, Sirikul W, Thongkum W, Soponpong S, Yasamut U, Kiratipaisarl W, Kosai A, Kasinrerk W, Tayapiwatana C, Srithanaviboonchai K. Dynamic of anti-spike receptor binding domain (RBD) levels and short-term adverse events following a heterologous booster dose of BNT162b2 after two doses of CoronaVac in Thai health care workers. Vaccine 2022;40(21):2915-24.
  • 15. Yimcharoen M, Saikaew S, Wattananandkul U, Phunpae P, Intorasoot S, Kasinrerk W, Tayapiwatana C, Butr-Indr B. The regulation of ManLAM-related gene expression in Mycobacterium tuberculosis with different drug resistance profiles following isoniazid treatment. Infect Drug Resist 2022;5(15):399-412.
  • 16. Towiboon P, Saenphet K, Tayapiwattana C, Tangyuenyong S, Watanabe G, Mahasawangkul S, Brown JL, Thitaram C. Relationship among serum progestagens, cortisol, and prolactin in pregnant and cycling Asian elephants in Thailand. Vet Sci 2022;9(5):244. doi 10.3390/vetsci9050244.
  • 17. Chupradit K, Sornsuwan K, Saiprayong K, Wattanapanitch M, Tayapiwatana C. Validation of promoters and codon optimization on CRISPR/Cas9-engineered Jurkat cells stably expressing Rep4E3 for interfering with HIV-1 replication. Int. J. Mol. Sci 2022;23(23):15049. doi 10.3390/ijms232315049.
  • 18. Yasamut U, Wisitponchai T, Lee VS, Yamabhai M, Rangnoi K, Thongkum W, Chupradit K, Tayapiwatana C. Determination of a distinguished interferon gamma epitope recognized by monoclonal antibody relating to autoantibody associated immunodeficiency. Sci Rep 2022;12(1):7608. doi 10.1038/s41598-022-11774-9.
  • 19. Sornsuwan K, Thongkhum W, Pamonsupornwichit T, Carraway TS, Soponpong S, Sakkhachornphop S, Tayapiwatana C, Yasamut U. Performance of affinity-improved DARPin targeting HIV capsid domain in interference of viral progeny production. Biomolecules 2021;11(10):1437. doi 10.3390/biom11101437.
  • 20. Chupradit K, Thongkum W, Juntit OA, Sornsuwan K, Tayapiwatana C. 2LTRZFP Interacts specifically to HIV-1 DNA without off-target effects as determined by bolayer interferometry. Biosensors (Basel) 2021;11(3):76.doi 10.3390/bios11030076.
  • 21. Thongkum W, Yasamut U, Chupradit K, Sakkhachornphop S, Wipasa J, Sornsuwan K, Juntit OA, Pornprasit R, Thongkamwitoon W, Chaichanan J, Khaoplab J, Chanpradab C, Kasinrerk W, Tayapiwatana C. Latticed gold nanoparticle conjugation via monomeric streptavidin in lateral flow assay for detection of autoantibody to interferon-gamma. Diagnostics (Basel) 2021;11(6):987.doi 10.3390/diagnostics11060987.
  • 22. Jiranusornkul S, Wongrattanakamon P, Hongwiset D, Sakkhachornphop S, Tayapiwatana C. Molecular modeling for a comparative analysis of interactions between 2LTRZFP and 2-LTR-circle junctions. Int J Pept Res Ther 2021;27(2):1373-84.
  • 23. Sornsuwan K, Thongkhum W, Pamonsupornwichit T, Carraway TS, Soponpong S, Sakkhachornphop S, Tayapiwatana C, Yasamut U. Performance of affinity-improved DARPin targeting HIV capsid domain in interference of viral progeny production. Biomolecules 2021;30(11):1437. doi 10.3390/biom11101437.
  • 24. Chong WL, Chupradit K, Chin SP, Khoo MM, Khor SM, Tayapiwatana C, Nimmanpipug P, Thongkum W, Lee VS. Protein-protein interactions: insight from molecular dynamics simulations and nanoparticle tracking analysis. Molecules 2021;26(18):5696. doi 10.3390/molecules26185696.
  • 25. Hadpech S, Peerakam N, Chupradit K, Tayapiwatana C. Occupation of a thermoresistant-scaffold (αRep) at SP1-NC cleavage site disturbs the function of HIV-1 protease. Biosci Rep 2020;40(6):BSR20201131. doi 10.1042/BSR20201131.

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