แขนงวิชาจุลชีววิทยาคลินิก

ผู้ช่วยศาสตราจารย์ ดร.ขจรศักดิ์   ตระกูลพัว

แขนงวิชาจุลชีววิทยาคลินิก
  :  khajornsak.tr@cmu.ac.th
  :  053-935086

ประวัติการศึกษา

  • วท.ด. (วิทยาศาสตร์ชีวการแพทย์)
  • วท.ม. (ชีววิทยา)
  • วท.บ. (เทคนิคการแพทย์)

Research Expertise

  • Propolis nanoparticles fabrication
  • Virulence factors of pathogenic yeasts and M. tuberculosis

  • 1. Thammasit P, Iadnut A, Mamoon K, Khacha-ananda S, Chupradit K, Tayapiwatana C, Kasinrerk W, Tragoolpua Y, Tragoolpua K. . A potential of propolis on major virulence factors of Cryptococcus neoformans.. Microb Pathog 2018;123(-):296-303.
  • 2. Poolperm P, Apinda N, Kataoka Y, Suriyasathaporn W, Tragoolpua K, Sawada T, Sthitmatee N. . Protection against Pasteurella multocida conferred by an intranasal fowl cholera vaccine in Khaki Campbell ducks.. JPN J Vet Res 2018;66(4):239-250.
  • 3. Putim C, Phaonakrop N, Jaresitthikunchai J, Gamngoen R, Tragoolpua K, Intorasoot S, Anukool U, Tharincharoen CS, Phunpae P, Tayapiwatana C, Kasinrerk W, Roytrakul S, Butr-Indr B. . Secretome profile analysis of multidrug-resistant, monodrug-resistant and drug-susceptible Mycobacterium tuberculosis.. Arch Microbiol. 2018;200(2):299-309.
  • 4. Tankaew P, Srisawat W, Singhla T, Tragoolpua K, Kataoka Y, Sawada T, Sthitmatee N. . . J Microbiol Methods 2018;145(-):20-27.
  • 5. Khacha-ananda S, Saenphet K, Saenphet S, Tragoolpua K, Chantawannakul P, Tragoolpua Y. . Evaluation of the stability of propolis granule and toxicity study in Wistar rats. . Chiang Mai J Sci. 2018;45(1):162-176.
  • 6. Panich T, Tragoolpua K, Pata S, Tayapiwatana C, Intasai N. . Downregulation of extracellular matrix metalloproteinase inducer by scFv-M6-1B9 intrabody suppresses cervical cancer invasion through inhibition of urokinase-type plasminogen activator . Cancer Biother Radiopharm. 2017;32(1):1-8.
  • 7. Poolperm P, Varinrak T, Kataoka Y, Tragoolpua K, Sawada T, Sthitmatee N. . Development and standardization of an in-house indirect ELISA for detection of duck antibody to fowl cholera. . J Microbiol Methods. 2017;142(-):10-14.
  • 8. Khacha-Ananda S, Tragoolpua K, Chantawannakul P, Tragoolpua Y. . Propolis extracts from the northern region of Thailand suppress cancer cell growth through induction of apoptosis pathways . Invest New Drugs. 2016;34(6):707-722.
  • 9. Kaewkod T, Tragoolpua K, Tragoolpua Y. Encapsulation of Artocarpus lacucha Roxb. extract in alginate chitosan nanoparticles for inhibition of methicillin resistant Staphylococcus aureus and bacteria causing skin diseases . Chiang Mai J Sci. 2016;43(5):946-958.
  • 10. Intorasoot S, Tharinjaroen CS, Phunpae P, Butr-Indr B, Anukool U, Intachai K, Orrapin S, Apiratmateekul N, Arunothong S, Suthachai V, Saengsawang K, Khamnoi P, Pata S, Kasinrerk W, Tragoolpua K. . Novel potential diagnostic test for Mycobacterium tuberculosis complex using combined immunomagnetic separation (IMS) and PCR-CTPP. J Appl Microbiol. 2016;121(2):528-538.
  • 11. Tharinjaroen CS, Intorasoot S, Anukool U, Phunpae P, Butr-Indr B, Orrapin S, Sangboonruang S, Arunothong S, Chaiyasirinroj B, Kunyanone N, Kasinrerk W, Tragoolpua K. . Novel targeting, lepB Gene, using polymerase chain reaction with confronting two pair primers (PCR-CTPP) for simultaneous detection of Mycobacterium tuberculosis complex and Mycobacterium bovis.. J Med Microbiol. 2016;65(-):36-43.
  • 12. Intasai N, Pata S, Tragoolpua K, Tayapiwatana C. . Recombinant multivalent EMMPRIN extracellular domain induces U937 human leukemia cell apoptosis by downregulation of monocarboxylate transporter 1 and activation of procaspase-9. . Appl Biochem Biotech. 2015;176(6):1781-90.
  • 13. Thammasit P, Sangboonruang S, Suwanpairoj S, Khamaikawin W, Intasai N, Kasinrerk W, Tayapiwatana C, Tragoolpua K. . Intracellular acidosis promotes mitochondrial apoptosis pathway: Role of EMMPRIN down-regulation via specific single-chain Fv intrabody. . J Cancer 2015;6(3):276-286.
  • 14. Sangboonruang S, Thammasit P, Intasai N, Kasinrerk W, Tayapiwatana C, Tragoolpua K. . EMMPRIN reduction via scFv-M6-1B9 intrabody affects alpha3beta1-integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2. . Cancer Gene Therapy. 2014;21(6):246-255.
  • 15. Tipattaraporn Panich, Pacharaphat Mangchak, Supansa Pata, Khajornsak Tragoolpua, Chatchai Tayapiwatana, Nutjeera Intasai. . CD147 scFv intrabody-mediated CD147 knockdown inhibits proliferation of human cervical cancer HeLa cells. . Bull Chiang Mai Assoc Med Sci 2014;1(9):30-36.
  • 16. Khacha-Ananda S, Tragoolpua K, Chantawannakul P, Tragoolpua Y. . Antioxidant and anti-cancer cell proliferation activity of propolis extracts from two extraction methods. . Asian Pac J Cancer Prev. 2013;14(11):6991-5.
  • 17. Liu Y, Tuve S, Persson J, Beyer I, Yumul R, Li ZY, Tragoolpua K, Hellström KE, Roffler S, Lieber A. . Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.. Cancer Gene Ther. 2011;18(6):407-418.
  • 18. Tuve S, Liu Y, Tragoolpua K, Jacobs JD, Yumul RC, Li ZY, Strauss R, Hellström KE, Disis ML, Roffler S and Lieber A. . In situ adenovirus vaccination engages T effector cells against cancer. . Vaccine 2009;27(31):4225-39..
  • 19. Intorasoot S, Thongpung R, Tragoolpua K, Chottayaporn M. . Hemoglobin E detection using PCR with confronting two-pair primers. . J Med Assoc Thai. 2008;91(11):1677-80.
  • 20. Tragoolpua K, Intasai N, Kasinrerk W, Mai S, Yuan Y, Tayapiwatana C. . Generation of functional scFv intrabody to abate the expression of CD147 surface molecule of 293A cells. . BMC Biotechnol. 2008;8(-):5-17.
  • 21. Intasai N, Tragoolpua K, Pingmuang P, Khunkaewla P, Moonsom S, Kasinrerk W, Lieber A, Tayapiwatana C. . Potent inhibition of OKT3-induced T cell proliferation and suppression of CD147 cell surface expression in HeLa cells by scFv-M6-1B9.. Immunobiol 2009 Jun 214; 410-21 2008;214(6):410-421.
  • 22. Nimsung R, Tragoolpua K, Preechasuth K, Kamsaiyai W, Pechdee W. . Production of reagent kit for quantitation of bilirubin in serum using bilirubin oxidase. . J Med Tech Assoc Thailand. 2006;64(3):1685-99.
  • 23. Boonchawalit T, Tragoolpua K, Saisawadi S, Nimsung R. . Evaluation of lyophilized bilirubin oxidase for use in determination of total bilirubin in serum by kinetic method.. Bull Chiang Mai Assoc Med Sci 2006;39(2):15-24.
  • 24. Pornprasert S, Chotayaporn M, Pratanphon R, Tragoolpua K. . Comparison of cell-mediated immune response to Penicillium marneffei antigen in the secreted and sonicated form. . J Med Tech Assoc Thailand 2004;32(-):672-82.
  • 25. Nishikawa Y, Tragoolpua K, Makala L, Xuan X, Nagasawa H. . Neospora caninum NcSRS2 is a transmembrane protein that contains a glycosylphosphatidylinositol anchor in insect cells. . Vet Parasitol. 2002;109(3-4):191-201.
  • 26. Nishikawa Y, Tragoolpua K, Inoue N, Makala L, Nagasawa H, Otsuka H, Mikami T. . In the absence of endogenous gamma interferon, mice acutely infected with Neospora caninum succumb to a lethal immune response characterized by inactivation of peritoneal macrophages.. Clin Diagn Lab Immunol. 2001;8(4):811-816.
  • 27. Nishikawa Y, Kousaka Y, Tragoolpua K, Xuan X, Makala L, Fujisaki K, Mikami T, Nagasawa H. . Characterization of Neospora caninum surface protein NcSRS2 based on baculovirus expression system and its application for serodiagnosis of Neospora infection. . J Clin Microbiol. 2001;39(11):3987-91.

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