Department of Medical Technology | Faculty of Associated Medical Sciences

Research Expertise

Hereditary red blood cell disorders
Hematologic stem/ progenitor cell culture
Molecular genetics and genetic engineering in blood disorders
Novel therapeutic approaches for blood disorders

ผลงานทางวิชาการ

Khamphikham P, Tepakhan W, Tongjai S, Jan-Ngam V, Laonan A, Thimsin W, Boontha S, Santiyos S, Pornprasert S. Identification of a novel and rare α0 -thalassemia 27.0 kb deletion with 9 bp insertion (Lamphun deletion; --LAMPHUN ) in a Thai family. Int J Lab Hematol 2024;46(1):176-179.
Osiriphan M, Insukhin C, Anuchapreeda S, Khamphikham P, Duangmano S. MicroRNA‑223 overexpression suppresses protein kinase C ε expression in human leukemia stem cell‑like KG‑1a cells. Mol Clin Oncol 2024;21(1):48.
Jan-Ngam V, Boontha S, Tubsuwan A, Wongpalee SP, Fanhchaksai K, Tantiworawit A, Charoenkwan P, Khamphikham P. Genetic modifications of EGLN1 reactivate HbF production in β0-thalassemia/HbE. Heliyon 2024;10(18):e38020.
Wongkhammul N, Khamphikham P, Tongjai S, Tantiworawit A, Fanhchaksai K, Wongpalee SP, Tubsuwan A, Maneekesorn S, Charoenkwan P. Erythropoiesis and gene expression analysis in erythroid progenitor cells derived from patients with hemoglobin H/Constant Spring disease. Int J Mol Sci 2024;25(20):11246.
Lin Y, Lin F, Zhang Z, Peng L, Yang W, Yang M, Luo B, Wu T, Li D, Li X, Ran B, Anuchapreeda S, Chaiwongsa R, Khamphikham P, Duangmano S, Xu J, He T, Pornprasert S. The FGFR1 signaling pathway upregulates the oncogenic transcription factor FOXQ1 to promote breast cancer cell growth. Int J Biol Sci 2023;19(3):744-759.
Khamphikham P, Hanmanoviriya O, Wongpalee SP, Munkongdee T, Paiboonsukwong K, Jopang Y, Wangchauy C, Sancharernsook C, Jinorose N, Pornprasert S. Development of molecular diagnostic platform for α0 -thalassemia 44.6 kb (Chiang Rai, --CR ) deletion in individuals with microcytic red blood cells across Thailand. Ann Hum Genet 2023;87(3):137-145.
Ruengdit C, Khamphikham P, Punyamung M, Pongpunyayuen P, Pornprasert S. Diagnosis of α0-thalassemia Chiang Rai (--CR) deletion by melt curve analysis in Northern Thailand. Scand J Clin Lab Invest 2022;82(3):181-184.
Khamphikham P, Wongborisuth C, Pornprasert S, Tantiworawit A, Tangprasittipap A, Songdej D, Hongeng S. IOX1 fails to reduce α-globin and mediates γ-globin silencing in adult β0-thalassemia/hemoglobin E erythroid progenitor cells. Exp Hematol 2022;112-113(-):9-14.e7.
Pornprasert S, Pongpunyayuen P, Chairatanapiwong S, Lawapakull P, Kulawong P, Jaiyasen T, Khamphikham P, Intasai N. Efficiency of lyophilized hemolysate control material in proficiency testing program for G6PD deficiency screening in Thailand. Int J Lab Hematol 2022;44(4):e160-e163.
Khamphikham P, Sakkhachornphop S, Pongsatha S, Pornprasert S. Strong positive dichlorophenolindophenol precipitation suggests Hb Dhonburi (or Hb Neapolis) (HBB: c.380T>G) inheritance in a couple at risk for severe β-thalassemia. Hemoglobin 2022;46(3):184-186.
Ruengdit C, Khamphikham P, Jinorose N, Pornprasert S. Hb Bart's hydrops fetalis syndrome and Hb H disease caused by deletional Chiang Rai (- -CR) α0-thalassemia in two unrelated Thai families. Hemoglobin 2021;45(2):75-79.
Khamphikham P, Jearawiriyapaisarn N, Tangprasittipap A, Hongeng S. Downregulation of KLF4 activates embryonic and fetal globin mRNA expression in human erythroid progenitor cells. Exp Ther Med 2021;22(4):1105.
Ruengdit C, Punyamung M, Khamphikham P, Pongpunyayuen P, Intasai N, Pornprasert S. Multiplex quantitative real-time polymerase chain reaction and high-resolution melting analysis for identification of a couple at-risk of having a newborn with severe thalassemia. Hemoglobin 2021;45(5):309-313.
Suriyun T, Kaewsakulthong W, Khamphikham P, Chumchuen S, Hongeng S, Fucharoen S, Sripichai O. Association of the degree of erythroid expansion and maturation arrest with the clinical severity of β0-thalassemia/hemoglobin E patients. Acta Haematol 2021;144(6):660-671.
Nualkaew T, Khamphikham P, Pongpaksupasin P, Kaewsakulthong W, Songdej D, Paiboonsukwong K, Sripichai O, Engel JD, Hongeng S, Fucharoen S, Jearawiriyapaisarn N. UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells. Ann Hematol 2020;99(9):2027-2036.
Khamphikham P, Nualkaew T, Pongpaksupasin P, Kaewsakulthong W, Songdej D, Paiboonsukwong K, Engel JD, Hongeng S, Fucharoen S, Sripichai O, Jearawiriyapaisarn N. High-level induction of fetal haemoglobin by pomalidomide in β-thalassaemia/HbE erythroid progenitor cells. Br J Haematol 2020;189(6):e240-e245.
Khamphikham P, Sripichai O, Munkongdee T, Fucharoen S, Tongsima S, Smith DR. Genetic variation of Krüppel-like factor 1 (KLF1) and fetal hemoglobin (HbF) levels in β0-thalassemia/HbE disease. Int J Hematol 2018;107(3):297-310.

รางวัล

Author : The best poster presentation award: August 21st-23rd 2019 Poster presentation in the topic of “Repurposing of pomalidomide to induce fetal hemoglobin expression for β-thalassemia treatment”, 24th National Thalassemia Conference at Teak Garden Spa Resort, Chiang Rai, Thailand
Author : The best oral presentation award: March 27th-29th 2024 Oral presentation in the topic of “Induction of HSP70 after XPO1 inhibition by selinexor augments erythroid maturation in β-thalassemia”, 25th National Thalassemia Conference at Centara Life Government Complex Hotel & Convention Centre Chaeng Watthana, Bangkok, Thailand

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